Pregabalin significantly increases the risk of adverse events including weight gain, somnolence, dizziness, dry mouth, peripheral oedema, fatigue, visual disturbances, ataxia, non-peripheral oedema, vertigo and euphoria. However, morphine was used as rescue medication when VAS scores were >3, which is likely to have impacted on the rate of AEs in each group. The percentage of patients with “lancinating pain” at the end of the study was significantly lower in the pregabalin group than each of the other three groups . Sources of Cervicogenic Headache Among the Upper Cervical Synovial Joints, Health Care Provider Utilization of Prescription Monitoring Programs: A Systematic Review and Meta-Analysis, Headache Characteristics and Psychological Factors Associated with Functional Impairment in Individuals with Persistent Posttraumatic Headache, The Combination of Preoperative Pain, Conditioned Pain Modulation, and Pain Catastrophizing Predicts Postoperative Pain 12 Months After Total Knee Arthroplasty, About the American Academy of Pain Medicine, http://www.iasp-pain.org/Content/NavigationMenu/GeneralResourceLinks/PainDefinitions/default.htm, http://whqlibdoc.who.int/publications/9241544821.pdf, http://www.ema.europa.eu/docs/en_GB/document_library/EPAR_-_Product_Information/human/000546/WC500046602.pdf, http://labeling.pfizer.com/ShowLabeling.aspx?id=561, Receive exclusive offers and updates from Oxford Academic, Preventive Analgesia with Pregabalin in Neuropathic Pain from “Failed Back Surgery Syndrome”: Assessment of Sleep Quality and Disability, Comparative Efficacy of Oral Pharmaceuticals for the Treatment of Chronic Peripheral Neuropathic Pain: Meta-Analysis and Indirect Treatment Comparisons, Pregabalin Assay in a Patient with Widespread Neuropathic Pain and Late Onset Gluten Intolerance, Patient-reported Outcomes in Subjects with Neuropathic Pain Receiving Pregabalin: Evidence from Medical Practice in Primary Care Settings, DBRCT of amitriptyline vs gabapentin vs pregabalin vs placebo, Pain intensity (BPI-sf) and sleep (MOS-sleep), Copyright © 2021 American Academy of Pain Medicine. The studies are thus summarized descriptively. Pregabalin is an analgesic approved in Europe for the treatment of peripheral and central neuropathic pain . The most common AEs experienced by patients overall in the study were somnolence, dizziness, dry mouth, nausea, and constipation. Indeed, only one pregabalin randomized controlled trial was identified in the literature search for this review. Studies examining pregabalin in neuropathic cancer pain. The mechanism of action of pregabalin also requires further study. Consistent with these findings, there was only one double-blind, placebo-controlled, randomized trial of pregabalin that met the search criteria for this systematic review and only five publications in total (Table 0001). = MSc, MBA; M.N. The effect of gaba- If required, increase dose to 150 mg twice a day after 3–7 days, to a maximum of 300 mg twice a day after another 7 days.1 It may take several weeks to achieve maximal effect with pregabalin. Amitriptyline hydrochloride and pregabalin are effective treatments for neuropathic pain. Health professionals also need to stay up to date with the latest evidence as it emerges. At high doses, gabapentin has proven effective against neuropathic pain induced by diabetic neuropathy and postherpetic neuralgia. Neuropathic pain severely affects patients’ quality of life and is a significant burden on society and healthcare systems. Fact sheet: Immunoglobulin products in Australia: information about access and consent, Thyroid disease: challenges in primary care, A new Working Together agreement between CHF and NPS MedicineWise, the Pharmaceutical Benefits Scheme (PBS) website, Hunter New England Local Health District website, pain (utilise multidimensional tools, such as the Brief Pain Inventory, that provide information about pain history, intensity and associated disability), daily activities (e.g. The studies included one double-blind randomized controlled trial, one single-arm open-label study, two observational analyses, and one case report.